Description

n-(Phenylsulfonyl)-L-Proline-2-Carboxamide is a high-purity, non-natural amino acid derivative featuring a phenylsulfonyl protecting group. This compound is a critical chiral building block and intermediate in advanced organic synthesis, particularly valued for its role in constructing complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and other bioactive compounds. Its defined stereochemistry and functional groups make it essential for medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, including protease inhibitors and other small molecule drugs.
• Peptidomimetics & Constrained Peptides: Used to introduce proline-like, rigidified structures into peptide backbones to enhance metabolic stability and biological activity.
• Chemical Biology & Proteomics: Serves as a specialized building block for synthesizing activity-based probes or inhibitors to study enzyme function.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in catalytic asymmetric reactions to induce chirality in target molecules.
• Custom Synthesis & Contract Manufacturing: A vital raw material for CDMOs (Contract Development and Manufacturing Organizations) producing custom APIs and advanced intermediates for clients.
• Academic Research: Used in university and institutional labs for methodological development in organic chemistry and medicinal chemistry projects.

Basic Information

Product Name	n-(Phenylsulfonyl)-L-Proline-2-Carboxamide
CAS No.	839711-69-2
Molecular Formula	C12H14N2O4S
Molecular Weight	282.32 g/mol
Synonyms	L-Proline-2-carboxamide, N-(phenylsulfonyl)-; (2S)-1-(Benzenesulfonyl)pyrrolidine-2-carboxamide; N-Benzenesulfonyl-L-prolinamide; 839711-69-2; N-(Phenylsulfonyl)-L-proline amide; 1-(Phenylsulfonyl)-L-proline-2-carboxamide
EINECS	Contact for details

Quality Control

Our n-(Phenylsulfonyl)-L-Proline-2-Carboxamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and impurities is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent absorption of moisture from the air.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.