Description

6-(Trifluoromethyl)Quinolin-2(1H)-One is a high-value trifluoromethyl-substituted quinolinone derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring the electron-withdrawing trifluoromethyl group fused to a nitrogen-containing heterocycle, makes it indispensable for modulating the physicochemical and biological properties of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in oncology, CNS disorders, and anti-infective therapies.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the CF3 group enhances lipophilicity and metabolic stability.
• Material Science Precursor: Employed in the creation of advanced organic electronic materials, such as OLEDs and semiconductors, due to its electron-deficient aromatic system.
• Ligand and Catalyst Development: Serves as a backbone for designing novel chelating ligands and organocatalysts in asymmetric synthesis.
• Fluorine Chemistry Research: An important compound for studying structure-activity relationships (SAR) in fluorinated heterocycles.

Basic Information

Product Name	6-(Trifluoromethyl)Quinolin-2(1H)-One
CAS No.	835903-14-5
Molecular Formula	C10H6F3NO
Molecular Weight	213.16 g/mol
Synonyms	2-Hydroxy-6-(trifluoromethyl)quinoline; 6-(Trifluoromethyl)-2-quinolinol; 6-(Trifluoromethyl)-2(1H)-quinolinone; 6-Trifluoromethyl-1H-quinolin-2-one; 6-Trifluoromethylquinolin-2(1H)-one; 1H-Quinolin-2-one, 6-(trifluoromethyl)-; Quinolin-2(1H)-one, 6-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 6-(Trifluoromethyl)Quinolin-2(1H)-One is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and scale-up. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.