Description

1-Bromo-2-(Difluoromethoxy)-4-Nitrobenzene is a specialized halogenated aromatic compound featuring a unique difluoromethoxy substituent. This structural motif makes it a valuable and versatile building block in advanced organic synthesis, particularly for introducing fluorine-containing groups into target molecules. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, especially those requiring fluorinated aromatic systems for enhanced metabolic stability, bioavailability, or receptor binding affinity.
• Agrochemical Synthesis: Serves as a crucial precursor in the manufacture of advanced pesticides and herbicides, where the difluoromethoxy group can improve lipophilicity and biological activity.
• Material Science Research: Used in the synthesis of novel fluorinated polymers, liquid crystals, and organic electronic materials to modify electronic properties and stability.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for metal-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Stille) to construct complex biaryl structures.
• Nucleophilic Aromatic Substitution: The electron-deficient nitro group activates the aromatic ring for substitution reactions, allowing further functionalization.
• Fluorine Chemistry Exploration: An important reagent for studying the effects of the difluoromethoxy group in medicinal and materials chemistry.

Basic Information

Item	Details
Product Name	1-Bromo-2-(Difluoromethoxy)-4-Nitrobenzene
CAS No.	835633-47-1
Molecular Formula	C7H4BrF2NO3
Molecular Weight	268.01 g/mol
Synonyms	2-Bromo-1-(difluoromethoxy)-4-nitrobenzene; 4-Nitro-2-(difluoromethoxy)bromobenzene; 1-Bromo-2-difluoromethoxy-4-nitrobenzene; 2-(Difluoromethoxy)-4-nitro-1-bromobenzene; 2-(Difluoromethoxy)-1-bromo-4-nitrobenzene; 1-Bromo-2-(difluoromethoxy)-4-nitro-benzene; Benzene, 1-bromo-2-(difluoromethoxy)-4-nitro-
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-(Difluoromethoxy)-4-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.