Description

n-[3,5-Bis(Trifluoromethyl)Phenyl]-N'-[(1R,2R)-2-(Dimethylamino)-1,2-Diphenylethyl]-Thiourea is a specialized chiral thiourea derivative that serves as a highly effective organocatalyst. Its value lies in its ability to facilitate asymmetric synthesis with excellent enantioselectivity, which is critical for producing single-enantiomer intermediates in pharmaceutical and fine chemical manufacturing. This compound is essential for research chemists and process development scientists working in asymmetric catalysis, particularly for the synthesis of chiral amines, alcohols, and other high-value building blocks.

Application

• Asymmetric Organocatalysis: Employed as a chiral hydrogen-bond donor catalyst for a variety of enantioselective transformations, including Michael additions, Mannich reactions, and acylations.
• Pharmaceutical Intermediate Synthesis: Used in the research and development of active pharmaceutical ingredients (APIs) requiring high enantiomeric purity.
• Fine Chemical Production: Catalyzes the synthesis of enantiomerically pure flavors, fragrances, and agrochemical intermediates.
• Methodology Development: A valuable tool for academic and industrial research groups developing new catalytic asymmetric protocols.
• Ligand for Metal Complexes: Can act as a precursor or auxiliary ligand in the formation of chiral metal complexes for catalysis.

Basic Information

Product Name	n-[3,5-Bis(Trifluoromethyl)Phenyl]-N'-[(1R,2R)-2-(Dimethylamino)-1,2-Diphenylethyl]-Thiourea
CAS No.	834917-24-7
Molecular Formula	C25H23F6N3S
Molecular Weight	527.53 g/mol
Synonyms	(1R,2R)-N-[3,5-Bis(trifluoromethyl)phenyl]-N'-[2-(dimethylamino)-1,2-diphenylethyl]thiourea; (R,R)-Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-[2-(dimethylamino)-1,2-diphenylethyl]-; Takemoto Catalyst; Chiral Bifunctional Thiourea Catalyst; (R,R)-3,5-Bis(trifluoromethyl)phenyl Thiourea Derivative; Organocatalyst 834917-24-7
EINECS	Contact for details

Quality Control

Our production of this high-value organocatalyst adheres to strict quality control protocols to ensure batch-to-batch consistency and optimal catalytic performance. Every lot is characterized by advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm chemical identity, high purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.