Description

6-Chloro-3-Fluoro-2-Hydroxyquinoline is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its unique halogenated quinoline scaffold makes it a critical intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting infectious diseases, cancer, and central nervous system disorders.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the quinoline core.
• Material Science Research: Serves as a building block for creating organic ligands, fluorescent dyes, and advanced organic electronic materials.
• Chemical Biology Probes: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and as a scaffold for probe and tool compound development.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific halogenated quinoline derivatives.

Basic Information

Product Name	6-Chloro-3-Fluoro-2-Hydroxyquinoline
CAS No.	834883-95-3
Molecular Formula	C9H5ClFNO
Molecular Weight	197.59 g/mol
Synonyms	2-Hydroxy-6-chloro-3-fluoroquinoline; 6-Chloro-3-fluoroquinolin-2-ol; 3-Fluoro-6-chloro-2-hydroxyquinoline; 6-Chloro-3-fluoro-2(1H)-quinolinone; 834883-95-3; Quinoline, 6-chloro-3-fluoro-2-hydroxy-; 2-Quinolinol, 6-chloro-3-fluoro-
EINECS	Contact for details

Quality Control

Every batch of 6-Chloro-3-Fluoro-2-Hydroxyquinoline is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.