Description

3,4-Pyrrolidinediamine,(3R,4R)-Rel-(9Ci) is a high-purity, stereochemically defined chiral diamine building block with the CAS registry number 828928-28-5. This compound is a critical intermediate in the synthesis of complex, biologically active molecules, offering precise control over stereochemistry which is essential for pharmaceutical efficacy and safety. It is primarily required by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in areas such as enzyme inhibitors, receptor modulators, and other fine chemical syntheses.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of active pharmaceutical ingredients (APIs), especially in oncology and central nervous system (CNS) drug candidates.
• Asymmetric Catalyst Ligand Precursor: Used in the preparation of chiral ligands for metal-catalyzed asymmetric synthesis, enabling the production of enantiomerically pure compounds.
• Peptidomimetic Chemistry: Serves as a constrained scaffold for designing and synthesizing peptide analogs with enhanced metabolic stability and bioavailability.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and tool compounds for studying enzyme mechanisms and protein-protein interactions.
• Agrochemical Research: Utilized as a building block in the discovery of new chiral pesticides and herbicides with improved selectivity.
• Academic & Industrial R&D: Fundamental research material for methodological development in organic synthesis and medicinal chemistry.

Basic Information

Product Name	3,4-Pyrrolidinediamine,(3R,4R)-Rel-(9Ci)
CAS No.	828928-28-5
Molecular Formula	C4H11N3
Molecular Weight	101.15 g/mol
Synonyms	(3R,4R)-3,4-Diaminopyrrolidine; rel-(3R,4R)-3,4-Pyrrolidinediamine; (3R,4R)-3,4-Diaminotetrahydrofuran (tautomer); Pyrrolidine-3,4-diamine, (3R,4R)-rel-; 3,4-Diaminopyrrolidine, (3R,4R)-rel-; (3R*,4R*)-3,4-Pyrrolidinediamine; 828928-28-5; (rel)-(3R,4R)-3,4-Diaminopyrrolidine
EINECS	Contact for details

Quality Control

Our 3,4-Pyrrolidinediamine,(3R,4R)-Rel-(9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.