Description

1,4-Methanonaphthalene-5-Carbonitrile,1,4,4A,5,8,8A-Hexahydro-5-Methyl-8-Oxo-,(1R,4S,4Ar,5S,8As)-Rel-(9Ci) is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound matters for its role as a critical building block in the synthesis of complex organic molecules, particularly in medicinal chemistry. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the development of new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of novel therapeutic agents.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing.
• Asymmetric Synthesis: Utilized as a precursor or template for constructing complex molecules with specific stereochemistry.
• Fine Chemical Production: Acts as a specialized intermediate for the manufacture of high-value, low-volume fine chemicals.
• Academic Research: Used in university and institutional labs for methodological development and studying novel organic reactions.

Basic Information

Product Name	1,4-Methanonaphthalene-5-Carbonitrile,1,4,4A,5,8,8A-Hexahydro-5-Methyl-8-Oxo-,(1R,4S,4Ar,5S,8As)-Rel-(9Ci)
CAS No.	828248-61-9
Molecular Formula	C₁₃H₁₅NO₂
Molecular Weight	217.26 g/mol
Synonyms	(1R,4S,4aR,5S,8aS)-5-Methyl-8-oxo-1,4,4a,5,8,8a-hexahydro-1,4-methanonaphthalene-5-carbonitrile; rel-(1R,4S,4aR,5S,8aS)-1,4,4a,5,8,8a-Hexahydro-5-methyl-8-oxo-1,4-methanonaphthalene-5-carbonitrile; 1,4-Methanonaphthalene-5-carbonitrile, 1,4,4a,5,8,8a-hexahydro-5-methyl-8-oxo-, (1R,4S,4aR,5S,8aS)-rel-; 828248-61-9; Hexahydro-5-methyl-8-oxo-1,4-methanonaphthalene-5-carbonitrile (stereoisomer)
EINECS	Contact for details

Quality Control

Our 1,4-Methanonaphthalene-5-Carbonitrile,1,4,4A,5,8,8A-Hexahydro-5-Methyl-8-Oxo-,(1R,4S,4Ar,5S,8As)-Rel-(9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and chemical identity verification, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.