Description

1,3-Dioxolane, 2,2,4-Trimethyl-5-(Phenylmethyl)-, (4S,5R)- is a high-purity, chiral dioxolane derivative of significant interest in advanced organic synthesis. This compound serves as a valuable chiral building block and auxiliary, enabling the stereoselective construction of complex molecules. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs) and other fine chemicals where precise stereochemistry is critical.

Application

• Chiral Auxiliary in Asymmetric Synthesis: Used to induce stereoselectivity in key bond-forming reactions.
• Pharmaceutical Intermediate: A critical precursor in the synthesis of enantiomerically pure drug candidates and APIs.
• Advanced Material Research: Employed in the development of chiral ligands for catalysis and functional polymers.
• Agrochemical Synthesis: Utilized in the production of stereospecific pesticides and herbicides.
• Academic & Process Chemistry: A tool for methodological development and scale-up studies in organic chemistry laboratories.

Basic Information

Product Name	1,3-Dioxolane, 2,2,4-Trimethyl-5-(Phenylmethyl)-, (4S,5R)-
CAS No.	827609-00-7
Molecular Formula	C13H18O2
Molecular Weight	206.28 g/mol
Synonyms	(4S,5R)-2,2,4-Trimethyl-5-benzyl-1,3-dioxolane; (4S,5R)-5-(Phenylmethyl)-2,2,4-trimethyl-1,3-dioxolane; (4S,5R)-5-Benzyl-2,2,4-trimethyl-1,3-dioxolane; Chiral Benzyl Dioxolane; (S,R)-Configured Dioxolane Auxiliary; 827609-00-7; 1,3-Dioxolane, 2,2,4-trimethyl-5-(phenylmethyl)-, (4S,5R)-
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized using advanced analytical techniques including chiral HPLC, GC, NMR, and optical rotation measurement. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its organic solvent nature and high volatility, keep away from strong acids, heat, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Specific Rotation [α]	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.