Description

tert-Butyl 4-(quinazolin-4-yl)piperazine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a quinazoline-piperazine scaffold. This compound is of significant commercial importance for its role as a key building block in the synthesis of bioactive molecules, particularly kinase inhibitors. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics for oncology and other disease areas.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of targeted small-molecule drugs, especially protein kinase inhibitors.
• Oncology Research: Serves as a core scaffold for developing novel anti-cancer agents targeting specific signaling pathways.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to improve drug potency and selectivity.
• Contract Manufacturing (CMO): Supplied to custom synthesis organizations for the production of Active Pharmaceutical Ingredients (APIs) under cGMP conditions.
• Biochemical Research: Employed as a tool compound or ligand in biochemical assays to study enzyme function and inhibition.

Basic Information

Product Name	tert-Butyl 4-(quinazolin-4-yl)piperazine-1-carboxylate
CAS No.	827598-29-8
Molecular Formula	C₁₇H₂₂N₄O₂
Molecular Weight	314.39 g/mol
Synonyms	1-Boc-4-(quinazolin-4-yl)piperazine; tert-Butyl 4-(4-quinazolinyl)-1-piperazinecarboxylate; 4-(1-Boc-piperazin-4-yl)quinazoline; 1-Piperazinecarboxylic acid, 4-(4-quinazolinyl)-, 1,1-dimethylethyl ester; BOC-4-(quinazolin-4-yl)piperazine; 827598-29-8; 4-(Quinazolin-4-yl)piperazine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(quinazolin-4-yl)piperazine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.