Description

(2S,5R)-5-Hydroxypipecolic Acid Hcl is a high-purity, non-proteinogenic amino acid derivative belonging to the pipecolic acid family. This chiral building block is of significant value in pharmaceutical research and development, particularly for the synthesis of complex molecules and peptide mimetics. It is primarily utilized by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the creation of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, renin inhibitors, and other biologically active compounds.
• Peptidomimetics Research: Used to introduce constrained conformational elements into peptide backbones to enhance stability, bioavailability, and receptor selectivity.
• Medicinal Chemistry: Serves as a versatile scaffold for constructing libraries of novel chemical entities in drug discovery programs.
• Biochemical Research: Employed as a standard or reference compound in metabolic pathway studies and enzyme inhibition assays.
• Asymmetric Synthesis: Utilized as a starting material or auxiliary in stereoselective chemical transformations.
• API Process Development: Integrated into the synthetic route for advanced intermediates during the scale-up of candidate drugs.

Basic Information

Product Name	(2S,5R)-5-Hydroxypipecolic Acid Hydrochloride
CAS No.	824943-40-0
Molecular Formula	C6H11NO3 • HCl
Molecular Weight	197.62 g/mol
Synonyms	(2S,5R)-5-Hydroxypipecolic Acid Hydrochloride; (2S,5R)-5-Hydroxy-DL-pipecolic Acid HCl; (2S,5R)-5-Hydroxy-2-piperidinecarboxylic Acid Hydrochloride; 5-Hydroxy-D-pipecolic Acid Hydrochloride (stereoisomer); 5-Hydroxypipecolic Acid HCl (2S,5R); L-5-Hydroxypipecolic Acid Hydrochloride (related); 5-Hydroxy-DL-pipecolate Hydrochloride
EINECS	Contact for details

Quality Control

Our (2S,5R)-5-Hydroxypipecolic Acid Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (2S,5R)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.