Description

1-(6-Iodo-3,4-Dihydro-2H-[1,8]Naphthyridin-1-Yl)-2,2-Dimethyl-Propan-1-One is a high-purity, advanced pharmaceutical intermediate featuring a complex naphthyridine core structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting various therapeutic areas. It is primarily sought after by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in the development of new drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to develop new therapeutic molecules.
• API Development: Serves as a precursor in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Chemical Biology Probes: Utilized in the development of chemical probes for studying biological pathways and target validation due to its specific structural motifs.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs for custom synthesis projects and scale-up development.
• Academic Research: Employed in university and institutional laboratories for advanced organic synthesis and heterocyclic chemistry studies.

Basic Information

Product Name	1-(6-Iodo-3,4-Dihydro-2H-[1,8]Naphthyridin-1-Yl)-2,2-Dimethyl-Propan-1-One
CAS No.	824429-55-2
Molecular Formula	C13H15IN2O
Molecular Weight	342.18 g/mol
Synonyms	1-(6-Iodo-1,2,3,4-tetrahydro-1,8-naphthyridin-1-yl)-2,2-dimethylpropan-1-one; 2,2-Dimethyl-1-(1,2,3,4-tetrahydro-6-iodo-1,8-naphthyridin-1-yl)propan-1-one; 6-Iodo-1-(2,2-dimethyl-1-oxopropyl)-1,2,3,4-tetrahydro-1,8-naphthyridine; 1-(6-Iodo-3,4-dihydro-2H-[1,8]naphthyridin-1-yl)-2,2-dimethyl-1-propanone; CAS 824429-55-2
EINECS	Contact for details

Quality Control

Our 1-(6-Iodo-3,4-Dihydro-2H-[1,8]Naphthyridin-1-Yl)-2,2-Dimethyl-Propan-1-One is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.