Description

1-(3,4-Dihydro-2H-[1,8]Naphthyridin-1-Yl)-2,2-Dimethyl-Propan-1-One is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers requiring a reliable and consistent supply of sophisticated building blocks for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting neurological and oncological pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a precursor in multi-step synthetic routes for complex, high-value APIs.
• Chemical Biology Probes: Employed in the development of molecular probes for studying biological mechanisms and target validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.

Basic Information

Product Name	1-(3,4-Dihydro-2H-[1,8]Naphthyridin-1-Yl)-2,2-Dimethyl-Propan-1-One
CAS No.	824429-54-1
Molecular Formula	C13H18N2O
Molecular Weight	218.30 g/mol
Synonyms	1-(3,4-Dihydro-2H-[1,8]naphthyridin-1-yl)-2,2-dimethylpropan-1-one; 2,2-Dimethyl-1-(3,4-dihydro-2H-[1,8]naphthyridin-1-yl)propan-1-one; 1-(3,4-Dihydro-2H-[1,8]naphthyridin-1-yl)-2,2-dimethyl-1-propanone; Pivaloyl-1,8-naphthyridine derivative; 824429-54-1; 1-(3,4-dihydro-2H-1,8-naphthyridin-1-yl)-2,2-dimethylpropan-1-one
EINECS	Contact for details

Quality Control

Our 1-(3,4-Dihydro-2H-[1,8]Naphthyridin-1-Yl)-2,2-Dimethyl-Propan-1-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with every shipment, detailing all relevant specifications. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.