Description

5,7-Methanoquinoline-2-Methanol, 5,6,7,8-Tetrahydro-α,6,6-Trimethyl-, (5S,7S)- is a high-purity, stereochemically defined synthetic intermediate of significant interest in advanced organic synthesis. Its value lies in its complex, fused ring structure which serves as a versatile chiral building block for the development of novel active pharmaceutical ingredients (APIs) and specialty fine chemicals. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of complex molecules, particularly for applications in medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for central nervous system (CNS) and anti-infective drug candidates.
• Medicinal Chemistry Research: Used as a core scaffold or advanced precursor for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Asymmetric Synthesis: Employed in catalytic and stoichiometric asymmetric reactions to construct complex molecular architectures with high enantiomeric purity.
• Fine Chemical Production: Serves as a starting material for the synthesis of specialty chemicals, including ligands for catalysis and advanced materials.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant scale, focusing on yield optimization and impurity profile control.

Basic Information

Product Name	5,7-Methanoquinoline-2-Methanol, 5,6,7,8-Tetrahydro-α,6,6-Trimethyl-, (5S,7S)-
CAS No.	821799-11-5
Molecular Formula	C15H21NO
Molecular Weight	231.33 g/mol
Synonyms	(5S,7S)-5,6,7,8-Tetrahydro-α,6,6-trimethyl-5,7-methanoquinoline-2-methanol; (5S,7S)-α,6,6-Trimethyl-5,6,7,8-tetrahydro-5,7-methanoquinoline-2-methanol; (5S,7S)-THQ derivative; Chiral methanoquinoline methanol; Tetrahydro-methanoquinoline methanol isomer; (5S,7S)-TMMQ; (5S,7S)-enantiomer of CAS 821799-11-5.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to confirm identity, potency, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support compliance with ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.