Description

5,7-Methanoquinoline-2-carboxaldehyde, 5,6,7,8-tetrahydro-6,6-dimethyl-, (5S,7S)- is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex molecules, offering a precise chiral scaffold for medicinal chemistry research and development. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for creating novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of potential drug candidates, particularly in central nervous system (CNS) and antiviral research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its rigid, polycyclic framework.
• Process Chemistry Development: Employed in scaling up synthetic routes for new chemical entities (NCEs) under Good Manufacturing Practice (GMP) conditions.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in catalytic asymmetric transformations to introduce molecular complexity.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Academic Research: Used in university and institutional labs for methodological development in organic synthesis and chemical biology.

Basic Information

Product Name	5,7-Methanoquinoline-2-carboxaldehyde, 5,6,7,8-tetrahydro-6,6-dimethyl-, (5S,7S)-
CAS No.	821799-10-4
Molecular Formula	C₁₄H₁₇NO
Molecular Weight	215.29 g/mol
Synonyms	(5S,7S)-5,6,7,8-Tetrahydro-6,6-dimethyl-5,7-methanoquinoline-2-carboxaldehyde; (5S,7S)-6,6-Dimethyl-5,6,7,8-tetrahydro-5,7-methanoquinoline-2-carbaldehyde; (5S,7S)-THDQCA; (5S,7S)-Tetrahydrodimethylmethanoquinolinecarboxaldehyde; Chiral Methanoquinoline Aldehyde; (5S,7S)-Enantiomer of CAS 821799-10-4
EINECS	Contact for details

Quality Control

Our 5,7-Methanoquinoline-2-carboxaldehyde, 5,6,7,8-tetrahydro-6,6-dimethyl-, (5S,7S)- is manufactured under strict quality systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing identity, purity, and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (5S,7S)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.