Description

Chloro[(R)-(+)-5,5'-Dichloro-6,6'-Dimethoxy-2,2'-Bis(Diphenylphosphino)-1,1'-Biphenyl](p-Cymene)Ruthenium(II) Chloride CH2Cl2 Adduct is a high-purity, chiral ruthenium complex designed for advanced asymmetric catalysis. This compound matters as a highly efficient and selective catalyst for critical hydrogenation and transfer hydrogenation reactions, enabling the synthesis of enantiomerically pure intermediates. It is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require robust and reproducible catalytic performance.

Application

• Asymmetric Hydrogenation Catalyst: For the enantioselective reduction of ketones, imines, and olefins in pharmaceutical intermediate synthesis.
• Transfer Hydrogenation Reactions: Utilizing hydrogen donors like isopropanol or formic acid for selective reductions under mild conditions.
• Chiral Ligand Precursor: Serving as a source of the (R)-DIFLUORPHOS ligand analog for the development of other metal complexes.
• Process Chemistry & Scale-up: Enabling the development of efficient, scalable routes to active pharmaceutical ingredients (APIs) and agrochemicals.
• Academic & Industrial R&D: For methodological development in organic synthesis and catalysis research.
• Synthesis of Enantiopure Compounds: Production of chiral alcohols, amines, and other building blocks with high optical purity.

Basic Information

Product Name	Chloro[(R)-(+)-5,5'-Dichloro-6,6'-Dimethoxy-2,2'-Bis(Diphenylphosphino)-1,1'-Biphenyl](p-Cymene)Ruthenium(II) Chloride CH2Cl2 Adduct
CAS No.	821793-33-3
Molecular Formula	C53H48Cl4O2P2Ru • (CH2Cl2)x
Molecular Weight	Contact for details
Synonyms	(R)-Ru-DIFLUORPHOS(p-cymene)chloride Dichloromethane Adduct; (R)-[RuCl(p-cymene)((R)-5,5'-Dichloro-6,6'-dimethoxy-2,2'-bis(diphenylphosphino)-1,1'-biphenyl)]Cl•CH2Cl2; Ruthenium, chloro[(1,2,3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene][(5R)-5,5'-dichloro-6,6'-dimethoxy-2,2'-bis(diphenylphosphino)[1,1'-biphenyl]-2,2'-diyl]-, chloride, compd. with dichloromethane; (R)-DIFLUORPHOS-Ru(p-cymene) catalyst; Asymmetric Ruthenium DIFLUORPHOS Catalyst; Ru-((R)-DIFLUORPHOS)(p-cymene)Cl]Cl•CH2Cl2
EINECS	Contact for details

Quality Control

Our Chloro[(R)-(+)-5,5'-Dichloro-6,6'-Dimethoxy-2,2'-Bis(Diphenylphosphino)-1,1'-Biphenyl](p-Cymene)Ruthenium(II) Chloride CH2Cl2 Adduct is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high catalytic activity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and chiral analysis to verify enantiomeric integrity. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere (argon or nitrogen) due to its sensitivity to moisture and oxidation. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	Orange to red-brown crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Chiral Purity	≥ 99% ee
Solvent Content (CH2Cl2)	By NMR / Loss on Drying
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.