Description

5,7-Methanoquinoline-2-carboxaldehyde, 5,6,7,8-tetrahydro-6,6-dimethyl-, (5R,7R)- is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex molecules, offering a rigid, functionalized quinoline scaffold for medicinal chemistry and process development. It is primarily required by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and antiviral targets.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of novel drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its constrained, three-dimensional structure.
• Process Chemistry Development: Employed in route scouting and scale-up for the production of complex organic molecules.
• Asymmetric Synthesis: Utilized as a chiral template or ligand precursor in catalytic asymmetric transformations.
• Chemical Reference Standard: Acts as an analytical standard for quality control and method validation in API manufacturing.

Basic Information

Product Name	5,7-Methanoquinoline-2-carboxaldehyde, 5,6,7,8-tetrahydro-6,6-dimethyl-, (5R,7R)-
CAS No.	821774-82-7
Molecular Formula	C₁₅H₁₉NO
Molecular Weight	229.32 g/mol
Synonyms	(5R,7R)-5,6,7,8-Tetrahydro-6,6-dimethyl-5,7-methanoquinoline-2-carboxaldehyde; (5R,7R)-6,6-Dimethyl-5,6,7,8-tetrahydro-5,7-methanoquinoline-2-carbaldehyde; (5R,7R)-TDQC; (5R,7R)-Tetrahydrodimethylmethanoquinolinecarboxaldehyde; (5R,7R)-Methanoquinoline carboxaldehyde derivative; Chiral methanoquinoline aldehyde; 2-Formyl-5,6,7,8-tetrahydro-6,6-dimethyl-5,7-methanoquinoline (5R,7R)-isomer
EINECS	Contact for details

Quality Control

Our 5,7-Methanoquinoline-2-carboxaldehyde, 5,6,7,8-tetrahydro-6,6-dimethyl-, (5R,7R)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D and cGMP applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.