Description

4,4-Difluorobutan-1-Amine Hydrochloride is a high-purity, organofluorine building block essential for advanced chemical synthesis. This compound is valued for its role in introducing the difluoromethylene motif, a key structural element in modern pharmaceuticals and agrochemicals. It is primarily sought by research and development chemists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of protease inhibitors and other bioactive molecules containing fluorinated motifs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where fluorination enhances stability and biological activity.
• Material Science Research: Serves as a monomer or precursor for developing novel fluorinated polymers, coatings, and specialty materials with unique surface properties.
• Chemical Biology & Proteomics: Employed as a reagent for labeling and modifying biomolecules, aiding in drug discovery and biochemical research.
• Ligand & Catalyst Development: Used to synthesize novel fluorinated ligands for catalysis and molecular recognition applications.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects requiring specific, high-value fluorinated amine derivatives.

Basic Information

Product Name	4,4-Difluorobutan-1-Amine Hydrochloride
CAS No.	811842-33-8
Molecular Formula	C4H10ClF2N
Molecular Weight	145.58 g/mol
Synonyms	4,4-Difluorobutylamine hydrochloride; 1-Amino-4,4-difluorobutane hydrochloride; 4,4-Difluoro-1-butanamine hydrochloride; Butan-1-amine, 4,4-difluoro-, hydrochloride; 4,4-Difluorobutanamine HCl; 4,4-Difluorobutylammonium chloride
EINECS	Contact for details

Quality Control

Our 4,4-Difluorobutan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using a desiccator or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.