Description

4-[(4-Chlorophenyl)Amino]-7-Methoxyquinazolin-6-Ol is a high-purity, advanced pharmaceutical intermediate belonging to the quinazoline class of compounds. This compound is of significant commercial interest for its role as a key building block in the synthesis of targeted therapeutic agents. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of novel small-molecule drugs, particularly kinase inhibitors.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) for oncology and other therapeutic areas.
• Kinase Inhibitor Research: Used as a core scaffold in medicinal chemistry programs focused on designing and optimizing potent and selective kinase inhibitors.
• Biochemical Research: Employed as a reference standard or a tool compound in biochemical assays to study enzyme activity and signaling pathways.
• Process Development: Utilized in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific drug candidates.

Basic Information

Product Name	4-[(4-Chlorophenyl)Amino]-7-Methoxyquinazolin-6-Ol
CAS No.	808762-44-9
Molecular Formula	C15H12ClN3O2
Molecular Weight	301.73 g/mol
Synonyms	4-[(4-Chlorophenyl)amino]-7-methoxy-6-quinazolinol; 7-Methoxy-4-[(4-chlorophenyl)amino]quinazolin-6-ol; 6-Hydroxy-7-methoxy-4-[(4-chlorophenyl)amino]quinazoline; 4-(4-Chloroanilino)-7-methoxyquinazolin-6-ol; 808762-44-9; UNII-8Q2W7Q8K1G; 8Q2W7Q8K1G
EINECS	Contact for details

Quality Control

Our 4-[(4-Chlorophenyl)Amino]-7-Methoxyquinazolin-6-Ol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and stored in the original packaging away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.