Description

4-[(4-Chlorophenyl)Amino]-7-Methoxyquinazolin-6-Yl Acetate is a high-purity, advanced pharmaceutical intermediate belonging to the quinazoline class of compounds. This compound matters as a critical building block in the research and development of targeted therapeutic agents, particularly kinase inhibitors. Pharmaceutical R&D laboratories and fine chemical manufacturers need this precise intermediate to support the synthesis of novel drug candidates for oncology and other therapeutic areas.

Application

• Key intermediate in the synthesis of tyrosine kinase inhibitor (TKI) drug candidates.
• Research and development of targeted cancer therapies, particularly those targeting the EGFR pathway.
• Building block for pharmaceutical reference standards and analytical markers.
• Precursor in the development of novel quinazoline derivatives for biological screening.
• Used in process chemistry and scale-up studies for active pharmaceutical ingredient (API) manufacturing.
• Critical material for academic and industrial research in medicinal chemistry.

Basic Information

Product Name	4-[(4-Chlorophenyl)Amino]-7-Methoxyquinazolin-6-Yl Acetate
CAS No.	808762-43-8
Molecular Formula	C17H14ClN3O3
Molecular Weight	343.76 g/mol
Synonyms	6-Acetoxy-4-[(4-chlorophenyl)amino]-7-methoxyquinazoline; 4-(4-Chloroanilino)-7-methoxyquinazolin-6-yl acetate; 7-Methoxy-4-[(4-chlorophenyl)amino]quinazolin-6-ol acetate; 6-Acetyloxy-4-[(4-chlorophenyl)amino]-7-methoxyquinazoline; N-(4-Chlorophenyl)-7-methoxy-6-(acetyloxy)-4-quinazolinamine; 808762-43-8; 4-(p-Chloroanilino)-7-methoxy-6-acetoxyquinazoline
EINECS	Contact for details

Quality Control

Our 4-[(4-Chlorophenyl)Amino]-7-Methoxyquinazolin-6-Yl Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.