Description

Tricyclo[3.2.1.02,4]Octan-6-One, 3-(Hydroxymethyl)-, (1R,2R,3R,4S,5R)-Rel- (9Ci) is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound matters for its role as a critical chiral building block in the synthesis of complex, biologically active molecules, enabling precise control over the final product's pharmacological properties. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in areas requiring sophisticated organic synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and antiviral drugs.
• Asymmetric Synthesis: Utilized in catalytic and stoichiometric asymmetric reactions to construct complex polycyclic frameworks with high enantiomeric excess.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry Development: Used for scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Reference Standard: Acts as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical analysis.
• Academic Research: Applied in university and institutional labs for methodological development in organic and synthetic chemistry.

Basic Information

Product Name	Tricyclo[3.2.1.02,4]Octan-6-One, 3-(Hydroxymethyl)-, (1R,2R,3R,4S,5R)-Rel- (9Ci)
CAS No.	802911-81-5
Molecular Formula	C9H12O2
Molecular Weight	152.19 g/mol
Synonyms	rel-(1R,2R,3R,4S,5R)-3-(Hydroxymethyl)tricyclo[3.2.1.02,4]octan-6-one; 3-(Hydroxymethyl)tricyclo[3.2.1.02,4]octan-6-one, rel-(1R,2R,3R,4S,5R)-; Tricyclo[3.2.1.02,4]octan-6-one, 3-(hydroxymethyl)-, (1R,2R,3R,4S,5R)-rel-; Advanced Tricyclic Ketone Intermediate; Chiral Tricyclo[3.2.1.02,4]octane Derivative
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for pharmaceutical intermediates. We employ advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to verify identity, purity, and stereochemical integrity. Certificates of Analysis (COA) detailing batch-specific results are available upon request. Our quality management system supports development under cGMP guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.