Description

(2S)-1-(tert-Butoxycarbonyl)-2,5-Dihydro-1H-Pyrrole-2-Carboxylic Acid Diethylammonium Salt is a high-purity, protected amino acid derivative serving as a critical chiral building block in advanced organic synthesis. This compound is essential for researchers and manufacturers requiring precise stereochemistry and high chemical fidelity in complex molecular construction. It is primarily utilized in the development of active pharmaceutical ingredients (APIs), peptide mimetics, and other sophisticated fine chemicals where the integrity of the (2S) stereocenter is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Peptidomimetic Synthesis: Used to incorporate constrained proline-like structures into peptide backbones to enhance metabolic stability and biological activity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the preparation of chiral ligands and organocatalysts.
• Custom Chemical Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects requiring high stereochemical purity.
• Academic Research: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research laboratories.

Basic Information

Product Name	(2S)-1-(tert-Butoxycarbonyl)-2,5-Dihydro-1H-Pyrrole-2-Carboxylic Acid Diethylammonium Salt
CAS No.	800412-56-0
Molecular Formula	C16H30N2O4
Molecular Weight	314.42 g/mol
Synonyms	(2S)-1-Boc-2,5-dihydro-1H-pyrrole-2-carboxylic acid diethylammonium salt; Boc-DHP(2S)-OH·Et2NH; Diethylammonium (2S)-1-[(2-methylpropan-2-yl)oxycarbonyl]-2,5-dihydro-1H-pyrrole-2-carboxylate; (2S)-2,5-Dihydro-1H-pyrrole-2-carboxylic acid, 1-[(1,1-dimethylethoxy)carbonyl]-, compd. with N-ethylethanamine (1:1); 1-Boc-2,5-dihydro-L-proline diethylamine salt; (S)-1-(tert-Butoxycarbonyl)-2,5-dihydro-1H-pyrrole-2-carboxylic acid diethylammonium salt
EINECS	Contact for details

Quality Control

Our production of this chiral building block adheres to strict quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and optical rotation measurement. A comprehensive Certificate of Analysis (COA) detailing identity, purity (assay), enantiomeric excess, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.