Description

Iduronate 2-Sulfate is a specific, sulfated derivative of iduronic acid, a key monosaccharide component found in glycosaminoglycans (GAGs) like heparan sulfate and dermatan sulfate. This compound is of significant value as a high-purity biochemical standard and research reagent for studying enzyme kinetics, substrate specificity, and metabolic pathways related to GAG degradation. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and diagnostic kit manufacturers focused on lysosomal storage disorders, carbohydrate chemistry, and glycobiology.

Application

• Enzyme Substrate & Inhibitor Studies: Critical for assaying the activity of sulfatases, particularly iduronate-2-sulfatase (I2S), in research related to Hunter syndrome (MPS II).
• Biochemical Standard: Serves as a certified reference material for the calibration of analytical instruments (HPLC, MS) in quality control labs.
• Glycobiology Research: Used to investigate the structure-function relationship of heparan sulfate and its role in cell signaling, growth factor binding, and disease mechanisms.
• Diagnostic Development: Employed in the development and validation of enzymatic diagnostic assays for metabolic disorders.
• Pharmaceutical Intermediates: Acts as a potential intermediate or starting material in the synthesis of novel therapeutic agents targeting glycosaminoglycan metabolism.

Basic Information

Product Name	Iduronate 2-Sulfate
CAS No.	89846-17-3
Molecular Formula	C6H9O10S- (typically as a salt, e.g., sodium)
Molecular Weight	~289.19 g/mol (Free acid)
Synonyms	L-Iduronic acid 2-sulfate; 2-O-Sulfo-α-L-iduronic acid; Iduronate-2-sulfate; IdoA2S; 2-Sulfo-α-L-idopyranuronic acid; (2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-[(1S)-1-hydroxy-2-sulfooxyethyl]oxane-2-carboxylic acid; α-L-Idopyranuronic acid, 2-(hydrogen sulfate)
EINECS	Contact for details

Quality Control

Our Iduronate 2-Sulfate is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.