Description

1,2-Benzenediol, 3-Fluoro-5-(Hydroxymethyl)- is a fluorinated catechol derivative, a high-value fine chemical building block. Its unique structure, combining a diol, a fluoro substituent, and a hydroxymethyl group, makes it a versatile intermediate for synthesizing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries. Its precise reactivity profile enables the creation of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of fluorinated active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and plant growth regulators where the fluorine atom enhances bioactivity and stability.
• Ligand and Catalyst Development: Serves as a precursor for chelating ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Polymer Chemistry: Acts as a monomer or cross-linking agent for specialty polymers, including high-performance resins and fluorinated coatings.
• Material Science Research: Investigated for use in organic electronics, such as in the synthesis of components for organic light-emitting diodes (OLEDs) or conductive polymers.
• Biochemical Research: Utilized as a probe or inhibitor in enzymatic studies targeting catechol-O-methyltransferase (COMT) and related pathways.

Basic Information

Product Name	1,2-Benzenediol, 3-Fluoro-5-(Hydroxymethyl)-
CAS No.	89735-29-5
Molecular Formula	C7H7FO3
Molecular Weight	158.13 g/mol
Synonyms	3-Fluoro-5-(hydroxymethyl)benzene-1,2-diol; 3-Fluoro-5-(hydroxymethyl)catechol; 5-(Hydroxymethyl)-3-fluorobenzene-1,2-diol; 3-Fluoro-5-hydroxymethyl-1,2-benzenediol; Fluorocatechol derivative; FCHC
EINECS	Contact for details

Quality Control

We maintain a rigorous quality management system to ensure batch-to-batch consistency and high purity for this advanced intermediate. Production adheres to cGMP principles where applicable, and all materials are fully characterized. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, identity, and impurity profiles as determined by HPLC, GC, NMR, and MS. Our quality commitment ensures the material meets the exacting standards required for sensitive R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.