Description

7,8-Dihydroxy-9,10-Epoxy-8-Methyl-7,8,9,10-Tetrahydrobenzo(A)Pyrene is a highly specific and reactive metabolite of benzo[a]pyrene, a well-known polycyclic aromatic hydrocarbon (PAH). This compound is of critical importance in toxicological and carcinogenesis research as a key intermediate responsible for DNA adduct formation. It is primarily utilized by research institutions, pharmaceutical R&D departments, and environmental testing laboratories for mechanistic studies, biomarker development, and analytical reference standards.

Application

• Biochemical Research: Used as a critical reference standard and reagent in studies investigating the metabolic activation pathways of benzo[a]pyrene and its genotoxic effects.
• Toxicology Studies: Essential for in vitro and in vivo experiments to understand the mechanisms of PAH-induced carcinogenicity and to assess DNA damage.
• Analytical Chemistry: Serves as a high-purity calibration standard in advanced analytical techniques like HPLC-MS and GC-MS for the quantification of PAH metabolites in biological and environmental samples.
• Cancer Research: Employed to study the formation and repair of specific DNA adducts, aiding in the development of biomarkers for exposure assessment and cancer risk evaluation.
• Environmental Science: Used in method development and validation for monitoring human exposure to carcinogenic PAHs through their metabolic byproducts.
• Pharmaceutical Development: Acts as a tool compound in screening assays designed to identify potential chemopreventive agents that can inhibit metabolic activation or enhance detoxification pathways.

Basic Information

Product Name	7,8-Dihydroxy-9,10-Epoxy-8-Methyl-7,8,9,10-Tetrahydrobenzo(A)Pyrene
CAS No.	89524-81-2
Molecular Formula	C21H16O3
Molecular Weight	316.35 g/mol
Synonyms	BPDE; Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide (anti isomer); 7,8-Dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene; (+)-anti-BPDE; anti-Benzo[a]pyrene-7,8-diol-9,10-epoxide; 7,8-Dihydroxy-9,10-epoxy-8-methyl-tetrahydrobenzo[a]pyrene; Benzo[a]pyrene 7,8-diol 9,10-epoxide
EINECS	Contact for details

Quality Control

Our high-purity research-grade products undergo rigorous analytical characterization to ensure identity, purity, and stability. Each batch is supplied with a comprehensive Certificate of Analysis (COA) detailing results from HPLC, NMR, and MS analyses. We adhere to strict internal quality protocols to guarantee batch-to-batch consistency for your critical research applications. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and ensure long-term stability. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.