Description

4-Bromo-7-Trifluoromethylquinoline is a high-value halogenated and fluorinated quinoline derivative, serving as a critical building block in advanced organic synthesis. Its unique molecular structure, featuring both bromine and a trifluoromethyl group on the quinoline scaffold, makes it indispensable for creating complex molecules with tailored electronic and steric properties. This compound is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, antiviral agents, and other therapeutic small molecules.
• Agrochemical Research: Used to construct advanced active ingredients for crop protection products, leveraging the fluorine and bromine atoms to modulate bioactivity, stability, and environmental fate.
• Material Science: Serves as a monomer or functional unit in the development of organic electronic materials, such as OLEDs, due to the electron-withdrawing nature of the trifluoromethyl group.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis, where the quinoline core provides a rigid framework for metal coordination.
• Fluorine Chemistry: A valuable substrate for further functionalization via cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig), exploiting the reactive bromine site.

Basic Information

Product Name	4-Bromo-7-Trifluoromethylquinoline
CAS No.	89446-67-3
Molecular Formula	C10H5BrF3N
Molecular Weight	276.06 g/mol
Synonyms	7-(Trifluoromethyl)-4-bromoquinoline; 4-Bromo-7-(trifluoromethyl)quinoline; Quinoline, 4-bromo-7-(trifluoromethyl)-; 4-Bromo-7-trifluoromethyl-quinoline
EINECS	Contact for details

Quality Control

Our 4-Bromo-7-Trifluoromethylquinoline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support custom synthesis and can tailor purity grades to meet specific research or cGMP requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials. Due to its light-sensitive nature, handling should be conducted under appropriate conditions to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.