Description

Benzeneacetic Acid, -α--Ethyl-4-Methyl-, (-α-R)- (9Ci) CAS NO 89186-02-7 is a chiral, substituted phenylacetic acid derivative characterized by its specific stereochemistry at the alpha carbon. This compound is a high-value intermediate for the synthesis of complex organic molecules, where its defined stereocenter and functional groups are critical for directing chemical reactions and biological activity. It is primarily sought by pharmaceutical research and fine chemical synthesis sectors for developing active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of non-steroidal anti-inflammatory drugs (NSAIDs), receptor agonists/antagonists, and other bioactive molecules.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides where the specific stereochemistry influences efficacy.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis, enhancing the enantioselectivity of synthetic processes.
• Fine Chemical Manufacturing: Employed in custom synthesis and contract manufacturing for producing specialty chemicals with high purity requirements.
• Academic and R&D: Utilized in university and industrial research laboratories for methodological studies in organic synthesis and medicinal chemistry.
• Material Science: Potential monomer or modifier in the synthesis of specialized polymers with tailored properties.

Basic Information

Item	Detail
Product Name	Benzeneacetic Acid, -α--Ethyl-4-Methyl-, (-α-R)- (9Ci)
CAS No.	89186-02-7
Molecular Formula	C11H14O2
Molecular Weight	178.23 g/mol
Synonyms	(R)-2-Ethyl-2-(4-methylphenyl)acetic acid; (αR)-α-Ethyl-4-methylbenzeneacetic acid; (R)-2-(4-Methylphenyl)butanoic acid; (R)-4-Methylhydratropic acid; (R)-α-Ethyl-p-toluic acid; (R)-2-(p-Tolyl)butyric acid; (-)-α-Ethyl-4-methylbenzeneacetic acid; (R)-Tolylbutyric acid
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Quality is verified through advanced analytical techniques including chiral HPLC, GC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity (assay), enantiomeric excess (ee), and impurity profile is provided with each shipment. We support compliance with cGMP and ISO 9001 standards for relevant applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its acidic nature, store separately from strong bases, oxidizing agents, and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.