Description

(1S,2S)-1-Amino-1-Phenylpropan-2-Ol Hydrochloride is a high-purity chiral intermediate of significant commercial and research importance. This compound is valued for its role as a key building block in the synthesis of complex pharmaceutical molecules, particularly those requiring specific stereochemistry for biological activity. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in asymmetric synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the production of active pharmaceutical ingredients (APIs), especially in the development of adrenergic agents and central nervous system (CNS) drugs.
• Asymmetric Synthesis: Used as a precursor or resolving agent in stereoselective chemical reactions to create enantiomerically pure compounds.
• Medicinal Chemistry Research: Serves as a scaffold for structure-activity relationship (SAR) studies and the discovery of new therapeutic candidates.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals, flavors, and fragrances where precise chirality is required.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	(1S,2S)-1-Amino-1-Phenylpropan-2-Ol Hydrochloride
CAS No.	88784-93-4
Molecular Formula	C9H14ClNO
Molecular Weight	187.67 g/mol
Synonyms	(1S,2S)-(-)-2-Amino-1-phenyl-1-propanol hydrochloride; (1S,2S)-Norephedrine hydrochloride; (1S,2S)-1-Phenyl-2-aminopropanol hydrochloride; (1S,2S)-threo-1-Phenyl-2-aminopropan-1-ol hydrochloride; (-)-threo-2-Amino-1-phenyl-1-propanol hydrochloride; L-threo-1-Phenyl-2-aminopropanol hydrochloride; (1S,2S)-1-Phenylpropanolamine hydrochloride
EINECS	Contact for details

Quality Control

Our (1S,2S)-1-Amino-1-Phenylpropan-2-Ol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and fine chemical synthesis. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.