Description

(1R,2S)-1-Amino-1-Phenylpropan-2-Ol Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial importance. This compound is valued for its defined stereochemistry, which is critical for producing enantiomerically pure active pharmaceutical ingredients (APIs). It is primarily sought after by research institutions and manufacturers in the pharmaceutical and fine chemical sectors for the development and synthesis of advanced therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of enantiomerically pure APIs, particularly for central nervous system (CNS) and cardiovascular drugs.
• Asymmetric Synthesis: Used as a chiral auxiliary or resolving agent in stereoselective chemical reactions to control the formation of specific stereocenters.
• Research & Development: Serves as a standard or starting material in medicinal chemistry programs for exploring new drug candidates and pharmacophores.
• Fine Chemical Production: Employed in the multi-step synthesis of complex organic molecules requiring high stereochemical fidelity for agrochemicals or specialty chemicals.

Basic Information

Product Name	(1R,2S)-1-Amino-1-Phenylpropan-2-Ol Hydrochloride
CAS No.	88784-91-2
Molecular Formula	C9H14ClNO
Molecular Weight	187.67 g/mol
Synonyms	(1R,2S)-(-)-Norephedrine Hydrochloride; (1R,2S)-1-Phenyl-2-aminopropanol Hydrochloride; L(-)-Norephedrine Hydrochloride; (1R,2S)-2-Amino-1-phenyl-1-propanol Hydrochloride; (1R,2S)-threo-1-Phenyl-2-amino-1-propanol Hydrochloride; (-)-Threo-Norephedrine HCl; (1R,2S)-1-Phenylpropanolamine Hydrochloride
EINECS	Contact for details

Quality Control

Our (1R,2S)-1-Amino-1-Phenylpropan-2-Ol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and production. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.