Description

1-Nitrobenzo(A)Pyrene-7,8-Diol-9,10-Epoxide is a high-purity, synthetically derived metabolite and reference standard of the polycyclic aromatic hydrocarbon (PAH) Benzo[a]pyrene. This compound is of critical importance for research and analytical applications due to its role as a key reactive intermediate in the metabolic activation pathway of carcinogenic PAHs. It is primarily required by analytical laboratories, research institutions, and pharmaceutical companies engaged in toxicology studies, metabolic pathway research, and environmental contaminant analysis.

Application

• Analytical Reference Standard: For use as a primary standard in HPLC, GC-MS, and LC-MS methods to quantify PAH metabolites in complex matrices.
• Toxicology and Carcinogenicity Research: A vital reagent for in vitro and in vivo studies investigating the DNA-binding mechanisms and mutagenic potential of activated PAHs.
• Metabolic Pathway Studies: Used to study the cytochrome P450-mediated metabolic activation of Benzo[a]pyrene and related compounds.
• Environmental Monitoring: Calibration standard for detecting and measuring potent PAH-derived contaminants in environmental samples (air, water, soil).
• Biomarker Development: Employed in the development and validation of assays for PAH-DNA adducts, which serve as biomarkers of exposure and effect.
• Pharmaceutical Impurity Profiling: Reference material for identifying and controlling genotoxic impurities (PGIs) in active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1-Nitrobenzo(A)Pyrene-7,8-Diol-9,10-Epoxide
CAS No.	88598-54-3
Molecular Formula	C20H11NO5
Molecular Weight	345.31 g/mol
Synonyms	1-Nitrobenzo[a]pyrene-7,8-diol-9,10-epoxide; 1-Nitro-BPDE; 1-Nitrobenzo[a]pyrene 7,8-dihydrodiol 9,10-epoxide; 1-Nitro-B[a]PDE; 7,8-Dihydroxy-9,10-epoxy-7,8,9,10-tetrahydro-1-nitrobenzo[a]pyrene; 1-Nitro-BAP 7,8-diol-9,10-epoxide; 1-Nitro-BaP diol epoxide; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our 1-Nitrobenzo(A)Pyrene-7,8-Diol-9,10-Epoxide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research and analytical applications. Each lot is characterized using advanced spectroscopic and chromatographic techniques. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. Allow the sealed container to reach room temperature before opening to prevent moisture condensation. Keep away from strong oxidizers and bases.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.