Description

Ethyl 7-Chloro-6-Fluoro-1-(Formylmethylamino)-1,4-Dihydro-4-Oxoquinoline-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of novel fluoroquinolone antibiotics, a key class of broad-spectrum antimicrobial agents. It is essential for research and development laboratories, fine chemical manufacturers, and pharmaceutical companies engaged in the production of next-generation antibacterial therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) for fluoroquinolone antibiotics.
• Antibacterial Drug Research: Used in medicinal chemistry for the research and development of new antibacterial agents with improved efficacy and spectrum of activity.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for producing specialized chemical entities.
• Process Chemistry Development: Utilized for scaling up and optimizing synthetic routes for antibiotic production in pilot plants and commercial manufacturing.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory submissions in pharmaceutical development.

Basic Information

Product Name	Ethyl 7-Chloro-6-Fluoro-1-(Formylmethylamino)-1,4-Dihydro-4-Oxoquinoline-3-Carboxylate
CAS No.	88569-34-0
Molecular Formula	C₁₄H₁₂ClFN₂O₄
Molecular Weight	326.71 g/mol
Synonyms	7-Chloro-6-fluoro-1-[(formylmethyl)amino]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid ethyl ester; Ethyl 1-(N-formyl-N-methylamino)-7-chloro-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate; 1-(Formylmethylamino)-7-chloro-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl ester; Intermediate for Sitafloxacin; Sitafloxacin intermediate; DU-6859a intermediate; Fluoroquinolone intermediate CAS 88569-34-0
EINECS	Contact for details

Quality Control

Our Ethyl 7-Chloro-6-Fluoro-1-(Formylmethylamino)-1,4-Dihydro-4-Oxoquinoline-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.