Description

Gm2 n-Glycolylneuraminic Acid Ganglioside CAS NO 88528-32-9 is a specific, complex glycosphingolipid containing the non-human sialic acid derivative, N-glycolylneuraminic acid (Neu5Gc). This compound is a critical reference standard and research reagent for immunological and biochemical studies. It is primarily utilized by pharmaceutical R&D teams and academic research institutions investigating xenotransplantation, cancer immunology, and the role of Neu5Gc in human disease.

Application

• Biomedical Research Standard: Serves as a critical reference material for the identification and quantification of Neu5Gc-containing gangliosides in biological samples.
• Immunology Studies: Used to study anti-Neu5Gc antibody responses, which are significant in xenotransplantation rejection and certain inflammatory conditions.
• Cancer Research: Employed in investigating the role of dietary Neu5Gc incorporation into tumor cells and its implications for tumor immunology and progression.
• Diagnostic Development: Acts as a key antigen in the development and calibration of immunoassays and biosensors designed to detect Neu5Gc-specific antibodies or antigens.
• Glycobiology Research: Essential for studying the biosynthesis, catabolism, and function of non-human sialic acids in model systems.
• Vaccine Adjuvant Research: Investigated for its potential immunostimulatory properties in novel vaccine formulations.

Basic Information

Product Name	Gm2 n-Glycolylneuraminic Acid Ganglioside
CAS No.	88528-32-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Ganglioside GM2 (Neu5Gc); II3Neu5Gc-Gg4Cer; N-Glycolyl-GM2; GM2 Ganglioside containing N-glycolylneuraminic acid; Tay-Sachs ganglioside analog (Neu5Gc); Neu5Gc-GM2; Asialo-GM2 N-glycolyl derivative
EINECS	Contact for details

Quality Control

Our high-purity biochemical standards are produced and handled under controlled conditions to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analysis, including HPLC for purity and structural confirmation via mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and relevant analytical data.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid (lyophilized powder)
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Solubility	Soluble in chloroform/methanol/water mixtures

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.