Description

5-Fluoro-8-Methylquinoline is a high-purity, fluorinated quinoline derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role as a versatile intermediate in the development of pharmaceuticals, agrochemicals, and functional materials, where its unique substitution pattern enables precise molecular modifications. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active compounds and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for antimicrobial, anticancer, and central nervous system (CNS) active molecules.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and fungicides, leveraging the quinoline scaffold for bioactivity.
• Ligand and Catalyst Precursor: Serves as a starting material for synthesizing specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and conductive polymers, due to its electron-deficient quinoline core.
• Fluorescent Probe Development: Utilized as a core structure for creating sensitive fluorescent dyes and molecular probes for biochemical assays and imaging.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry, including cross-coupling and fluorination reactions.

Basic Information

Product Name	5-Fluoro-8-Methylquinoline
CAS No.	88474-18-4
Molecular Formula	C₁₀H₈FN
Molecular Weight	161.18 g/mol
Synonyms	8-Methyl-5-fluoroquinoline; 5-Fluoro-8-methyl-quinoline; Quinoline, 5-fluoro-8-methyl-; 5-Fluoro-8-methylchinolin; 88474-18-4; 5-Fluoro-8-methyl-quinoline
EINECS	Contact for details

Quality Control

Our 5-Fluoro-8-Methylquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Purity (GC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.