Description

L-Leucine Allyl Ester p-Toluenesulfonate Salt is a protected amino acid derivative, specifically the p-toluenesulfonate salt of L-leucine allyl ester. This compound is a crucial chiral building block and protecting group reagent in advanced organic synthesis, offering a reactive allyl ester moiety for peptide coupling and subsequent deprotection. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and other bioactive molecules where the stereochemical integrity of the L-leucine residue is essential.

Application

• Peptide Synthesis: Serves as a protected L-leucine derivative for the solid-phase and solution-phase synthesis of complex peptides and proteins.
• Pharmaceutical Intermediates: A key chiral intermediate in the research and development of active pharmaceutical ingredients (APIs), especially those containing leucine motifs.
• Bioconjugation & Prodrug Development: The allyl ester group is used in linker chemistry for bioconjugation strategies and as a prodrug moiety that can be cleaved under specific conditions.
• Chemical Biology Research: Employed in the synthesis of labeled amino acids, enzyme substrates, and inhibitors for biochemical and pharmacological studies.
• Material Science: Potential use in the synthesis of functionalized polymers and biomaterials where amino acid-based monomers are required.

Basic Information

Product Name	L-Leucine Allyl Ester p-Toluenesulfonate Salt
CAS No.	88224-03-7
Molecular Formula	C₁₇H₂₅NO₅S
Molecular Weight	355.45 g/mol
Synonyms	L-Leucine allyl ester tosylate salt; (S)-2-Amino-4-methylpentanoic acid allyl ester 4-methylbenzenesulfonate; Allyl L-leucinate p-toluenesulfonate; Leucine allyl ester tosylate; Tosic acid salt of L-leucine allyl ester; (S)-Allyl 2-amino-4-methylpentanoate 4-methylbenzenesulfonate; 88224-03-7; L-Leucine allyl ester TsOH salt
EINECS	Contact for details

Quality Control

Our L-Leucine Allyl Ester p-Toluenesulfonate Salt is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing identity, purity (typically ≥98%), and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	Contact for details
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.