Description

2,4-Dichloro-5-Fluoroquinazoline is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its core value lies in its versatile reactivity, where the chlorine and fluorine atoms serve as distinct handles for selective nucleophilic substitution, enabling the efficient construction of complex molecular architectures. This compound is critically needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly kinase inhibitors and other targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of various biologically active quinazoline derivatives, including tyrosine kinase inhibitors for oncology treatments.
• Agrochemical Synthesis: Used in the research and development of new herbicides and fungicides, leveraging the fluorinated quinazoline scaffold.
• Chemical Research & Development: Serves as a versatile scaffold for medicinal chemistry, enabling structure-activity relationship (SAR) studies and library synthesis.
• Material Science: Potential building block for the development of advanced organic electronic materials and fluorescent dyes.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific projects requiring functionalized quinazolines.

Basic Information

Product Name	2,4-Dichloro-5-Fluoroquinazoline
CAS No.	87611-00-5
Molecular Formula	C8H3Cl2FN2
Molecular Weight	217.03 g/mol
Synonyms	5-Fluoro-2,4-dichloroquinazoline; 2,4-Dichloro-5-fluoroquinazoline; Quinazoline, 2,4-dichloro-5-fluoro-; 87611-00-5; 5-Fluoro-2,4-dichloro-quinazoline; 2,4-Dichloro-5-fluoro-quinazoline
EINECS	Contact for details

Quality Control

Our 2,4-Dichloro-5-Fluoroquinazoline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.