Description

n-α-Palmitoyl-S-[2,3-Bis(Palmitoyloxy)-(2Rs)-Propyl]-L-Cysteine is a synthetic lipopeptide derivative, structurally related to the immunostimulatory component of bacterial cell walls. This compound is of significant interest for its role as a potent Toll-like receptor 2 (TLR2) agonist, making it a critical building block in advanced pharmaceutical and immunological research. It is primarily utilized by researchers and manufacturers developing novel vaccine adjuvants, immunotherapies, and drug delivery systems. The high-purity synthesis of this molecule is essential for ensuring reproducible biological activity in preclinical and clinical studies.

Application

• Vaccine Adjuvant Development: As a key component of synthetic lipopeptide adjuvants to enhance immune response.
• Immunological Research: Used as a tool compound to study TLR2-mediated signaling pathways and innate immune activation.
• Drug Delivery Systems: Incorporated into liposomal or nanoparticle formulations for targeted delivery.
• Pharmaceutical Intermediates: Serves as a critical synthetic intermediate for more complex immunomodulatory agents.
• Bioconjugation: Employed in the site-specific modification of proteins or peptides to impart immunostimulatory properties.

Basic Information

Product Name	n-α-Palmitoyl-S-[2,3-Bis(Palmitoyloxy)-(2Rs)-Propyl]-L-Cysteine
CAS No.	87420-41-5
Molecular Formula	C53H101NO7S
Molecular Weight	880.4 g/mol
Synonyms	Pam3Cys-Ser-(Lys)4 (common core structure reference); S-[2,3-Bis(palmitoyloxy)propyl]-N-palmitoyl-L-cysteine; Tripalmitoyl-S-glyceryl cysteine; TLR2 agonist lipopeptide; Synthetic macrophage-activating lipopeptide; MALP-2 analog; N-Palmitoyl-S-[2,3-bis(palmitoyloxy)propyl]cysteine
EINECS	Contact for details

Quality Control

Our production of n-α-Palmitoyl-S-[2,3-Bis(Palmitoyloxy)-(2Rs)-Propyl]-L-Cysteine adheres to stringent quality protocols suitable for research and pharmaceutical development. Each batch is characterized and tested to ensure high purity and structural integrity. Comprehensive analytical data, including HPLC, MS, and NMR, is provided. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Allow the container to reach room temperature before opening to minimize condensation and moisture uptake. Under these conditions, the product is typically stable for at least 24 months.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.