Description

trans-2,5-Bis-(Hydroxymethyl)-1,4-Dioxane is a versatile bifunctional chemical building block featuring a 1,4-dioxane ring substituted with hydroxymethyl groups. This compound matters for its unique structure, which serves as a key intermediate in synthesizing complex molecules, particularly in the pharmaceutical and polymer industries. It is primarily needed by R&D chemists and process engineers in fine chemical, pharmaceutical, and specialty polymer manufacturing for applications requiring a rigid, oxygenated scaffold with reactive hydroxyl functionality.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of chiral ligands, prodrugs, and active pharmaceutical ingredients (APIs) that incorporate a dioxane moiety.
• Polymer Chemistry: Serves as a monomer or cross-linking agent for the synthesis of novel polyethers, polyesters, and biodegradable polymers with tailored properties.
• Ligand Synthesis: Used in the development of chelating agents and catalysts for asymmetric synthesis and metal complexation.
• Fine Chemical Synthesis: An important building block for creating complex organic molecules in agrochemical and material science research.
• Cross-linking Agent: Utilized in the formulation of resins, coatings, and adhesives where its diol functionality can react with isocyanates or acids.
• Academic & Industrial R&D: A valuable reagent for exploring new synthetic methodologies and constructing molecular libraries.

Basic Information

Product Name	trans-2,5-Bis-(Hydroxymethyl)-1,4-Dioxane
CAS No.	87133-52-6
Molecular Formula	C6H12O4
Molecular Weight	148.16 g/mol
Synonyms	2,5-Bis(hydroxymethyl)-1,4-dioxane (trans-); (2R,5R)-2,5-Bis(hydroxymethyl)-1,4-dioxane; (2S,5S)-2,5-Bis(hydroxymethyl)-1,4-dioxane; trans-1,4-Dioxane-2,5-dimethanol; 1,4-Dioxane-2,5-dimethanol, (2R,5R)-rel-; 2,5-Di(hydroxymethyl)-1,4-dioxane; Dioxanedimethanol
EINECS	Contact for details

Quality Control

Our trans-2,5-Bis-(Hydroxymethyl)-1,4-Dioxane undergoes rigorous quality testing to ensure compliance with industry standards. We provide comprehensive analytical data to support your R&D and production needs. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request for every batch.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.