Description

4-Piperidinol, 1-(6-Chloro-4-(2-Chlorophenyl)-2-Quinazolinyl)-, Monohydrochloride is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) intermediate of significant pharmaceutical importance. Its core value lies in its critical role as a key building block in the synthesis of advanced antiviral and antiretroviral active pharmaceutical ingredients (APIs). This compound is essential for research institutions and pharmaceutical manufacturers engaged in the development and production of next-generation HIV treatments and other therapeutic agents targeting viral replication.

Application

• Pharmaceutical Intermediate: Primary use as a critical synthetic precursor for non-nucleoside reverse transcriptase inhibitor (NNRTI) drugs.
• Antiviral API Synthesis: Key building block in the manufacturing of active pharmaceutical ingredients for antiretroviral therapies, particularly for HIV treatment.
• Medicinal Chemistry Research: Valuable scaffold for drug discovery programs focused on viral diseases and enzyme inhibition.
• Process Development & Scale-up: Used in optimizing synthetic routes and scaling production for clinical trial material and commercial drug supply.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) specializing in complex pharmaceutical intermediates.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory submissions.

Basic Information

Product Name	4-Piperidinol, 1-(6-Chloro-4-(2-Chlorophenyl)-2-Quinazolinyl)-, Monohydrochloride
CAS No.	86892-32-2
Molecular Formula	C19H17Cl2N3O • HCl
Molecular Weight	411.72 g/mol (Free base: 374.27 g/mol)
Synonyms	1-(6-Chloro-4-(2-chlorophenyl)quinazolin-2-yl)piperidin-4-ol hydrochloride; 4-Hydroxy-1-[6-chloro-4-(2-chlorophenyl)-2-quinazolinyl]piperidine hydrochloride; NNRTI Intermediate; Efavirenz related intermediate; L-743,726 intermediate; 6-Chloro-4-(2-chlorophenyl)-2-(4-hydroxy-1-piperidinyl)quinazoline hydrochloride
EINECS	Contact for details

Quality Control

Our 4-Piperidinol, 1-(6-Chloro-4-(2-Chlorophenyl)-2-Quinazolinyl)-, Monohydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) are provided with each shipment, detailing comprehensive specifications and test results. We support compliance with cGMP, ICH Q7, and other relevant pharmaceutical guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.