Description

1-Piperazineacetic Acid, 4-Methyl-, (5-Bromo-2-Oxo-3-Indolinylidene)Hydrazide, Dihydrochloride, (Z)- is a high-purity, non-racemic chemical building block of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate for the creation of novel, targeted therapeutic agents. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and biotechnology industries working on kinase inhibitors and other small molecule drug candidates.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of targeted kinase inhibitors and other bioactive small molecules.
• Chemical Biology Research: Used as a probe or precursor in the study of enzyme mechanisms and cellular signaling pathways.
• Process Chemistry Development: Serves as a reference standard and starting material for scaling up synthetic routes under GMP conditions.
• Preclinical Candidate Synthesis: Integral component in the medicinal chemistry optimization cycle for lead compound generation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific novel chemical entities (NCEs).

Basic Information

Product Name	1-Piperazineacetic Acid, 4-Methyl-, (5-Bromo-2-Oxo-3-Indolinylidene)Hydrazide, Dihydrochloride, (Z)-
CAS No.	86873-25-8
Molecular Formula	C16H21BrCl2N6O2
Molecular Weight	480.19 g/mol
Synonyms	(Z)-1-(4-Methylpiperazin-1-yl)acetic acid (5-bromo-2-oxoindolin-3-ylidene)hydrazide dihydrochloride; 5-Bromo-3-[(2-[(4-methyl-1-piperazinyl)acetyl]hydrazono]-2-indolinone dihydrochloride; (5-Bromo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-[2-(4-methyl-piperazin-1-yl)-2-oxo-ethyl]-hydrazine dihydrochloride; 86873-25-8; (Z)-Isomer of the dihydrochloride salt.
EINECS	Contact for details

Quality Control

Our 1-Piperazineacetic Acid, 4-Methyl-, (5-Bromo-2-Oxo-3-Indolinylidene)Hydrazide, Dihydrochloride, (Z)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0% (Area Percent)
Chiral Purity (Chiral HPLC)	≥ 98.0% (Z)-Isomer
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.