Description

Bno-Peg5-Ch2Ch2Nh2 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a Boc-protected amine at one terminus and an amino group at the other, linked by a flexible pentameric ethylene glycol spacer. This compound is a critical intermediate for bioconjugation and linker chemistry, enabling the controlled attachment of biomolecules, drugs, or probes while providing solubility and reduced immunogenicity. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for developing advanced therapeutics and research tools.

Application

• Bioconjugation Linker: Used to covalently link peptides, proteins, antibodies, or oligonucleotides to other molecules, surfaces, or nanoparticles.
• ADC (Antibody-Drug Conjugate) Development: Serves as a functionalized PEG spacer in the synthesis of linkers for connecting cytotoxic payloads to monoclonal antibodies.
• PEGylation Reagent: Facilitates the site-specific PEGylation of therapeutic proteins to enhance pharmacokinetic properties such as solubility and circulation half-life.
• Cross-linking Agent: Employed in the preparation of hydrogels, polymer networks, and biomaterial scaffolds for tissue engineering and drug delivery systems.
• Diagnostic Probe Synthesis: Acts as a building block for constructing fluorescent, radioactive, or other labeled probes for imaging and detection assays.
• Solid-Phase Peptide Synthesis (SPPS): Used as a soluble, functionalized handle or as part of a cleavable linker system.
• Surface Functionalization: Applied to modify the surface of chips, sensors, or chromatography media with amine-reactive groups for biomolecule immobilization.

Basic Information

Product Name	Bno-Peg5-Ch2Ch2Nh2
CAS No.	86770-78-7
Molecular Formula	C24H48N2O8
Molecular Weight	492.66 g/mol
Synonyms	2-{2-[2-(2-{2-[(2-{[(tert-Butoxy)carbonyl]amino}ethyl)amino]ethoxy}ethoxy)ethoxy]ethoxy}ethylamine; Boc-NH-PEG5-NH2; Boc-Amine-PEG5-Amine; tert-Butyl N-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethyl]carbamate; Boc-N-amido-PEG5-amine; α-Boc-amino-ω-amino-pentaethylene glycol; Boc-PEG5-diamine; PEG5 Boc-amine amine
EINECS	Contact for details

Quality Control

Our Bno-Peg5-Ch2Ch2Nh2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight Confirmation (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.