Description

4A-Hydroxy Ivermectin is a key hydroxylated derivative of the broad-spectrum antiparasitic agent Ivermectin. This compound is of significant interest in pharmaceutical research and development, particularly for the synthesis of novel metabolites and analogs with potential therapeutic applications. It serves as a critical intermediate and reference standard for researchers and manufacturers in the veterinary and human pharmaceutical sectors, enabling advanced studies on metabolic pathways, efficacy, and safety profiles.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel Ivermectin derivatives and metabolites.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of Ivermectin-related products.
• Metabolic Studies: Employed in research to investigate the biotransformation and pharmacokinetic profile of Ivermectin.
• Veterinary Pharmaceutical R&D: Supports the development of next-generation antiparasitic formulations for animal health.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a precursor in the controlled synthesis of specialized APIs.
• Academic and Institutional Research: Utilized in universities and research institutes for pharmacological and parasitological studies.

Basic Information

Product Name	4A-Hydroxy Ivermectin
CAS No.	86629-74-5
Molecular Formula	C₄₈H₇₄O₁₅
Molecular Weight	891.1 g/mol
Synonyms	4α-Hydroxy Ivermectin; 4"-Hydroxy Ivermectin B1a; 4"-OH Ivermectin; Ivermectin 4"-Hydroxy Derivative; 4"-Hydroxy-22,23-dihydroavermectin B1a; 4α-Hydroxy-22,23-dihydroavermectin B1a; 4"-Hydroxy Ivermectin B1a Aglycone; 4α-Hydroxy Ivermectin B1a
EINECS	Contact for details

Quality Control

Our 4A-Hydroxy Ivermectin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets high-grade standards suitable for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.