Description

n-(Deoxyadenosin-8-Yl)-4-Aminobiphenyl is a specialized nucleoside adduct compound of significant interest in biochemical and toxicological research. This compound serves as a critical reference standard and biomarker for studying DNA damage and mutagenesis caused by aromatic amine exposure. It is primarily utilized by research institutions, diagnostic laboratories, and pharmaceutical companies engaged in carcinogenesis studies, analytical method development, and the safety assessment of chemical agents.

Application

• Biomarker Reference Standard: Used as a high-purity analytical standard for the quantification of DNA adducts in biological samples via techniques like 32P-postlabeling, LC-MS/MS, or immunoassays.
• Mechanistic Toxicology Research: Essential for investigating the metabolic activation, DNA binding specificity, and repair mechanisms of 4-aminobiphenyl and related aromatic amines.
• Carcinogenesis Studies: Employed in experimental models to understand the role of specific DNA lesions in the initiation of chemical carcinogenesis, particularly related to tobacco smoke and industrial chemical exposure.
• Analytical Method Development: Serves as a critical calibrant and positive control in the development and validation of sensitive assays for DNA damage detection.
• Educational & Diagnostic Tool: Used in academic settings for advanced teaching and in specialized diagnostic labs for exposure biomonitoring.

Basic Information

Product Name	n-(Deoxyadenosin-8-Yl)-4-Aminobiphenyl
CAS No.	86408-35-7
Molecular Formula	C22H22N6O3
Molecular Weight	418.45 g/mol
Synonyms	N-(Deoxyadenosin-8-yl)-4-aminobiphenyl; 8-(4-Aminobiphenyl-1-yl)-2'-deoxyadenosine; dA-ABP; ABP-dA Adduct; 4-Aminobiphenyl-deoxyadenosine Adduct; N-(2'-Deoxyadenosin-8-yl)-4-aminobiphenyl; DNA Adduct of 4-Aminobiphenyl; Contact for details on additional synonyms.
EINECS	Contact for details.

Quality Control

Every batch of n-(Deoxyadenosin-8-Yl)-4-Aminobiphenyl is produced and analyzed under strict quality protocols to ensure identity, purity, and stability for research applications. Our quality assurance includes comprehensive characterization by HPLC, NMR, and MS to confirm structural integrity and purity levels. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific data.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, controlled environment. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Off-white to light tan solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 2.0 %
Solubility	Soluble in DMSO, DMF; sparingly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.