Description

6-Fluorocholesterol is a fluorinated derivative of cholesterol, a key sterol in biological systems. This compound is of significant value as a biochemical tool and a stable, non-radioactive tracer for studying cholesterol metabolism, membrane dynamics, and protein-sterol interactions. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and life science sectors for advanced R&D applications.

Application

• Biochemical Research: Used as a stable analog to investigate cholesterol biosynthesis, trafficking, and homeostasis in cellular models.
• Membrane Studies: Serves as a probe to study the role of sterols in modulating membrane fluidity, permeability, and lipid raft formation.
• Drug Discovery: Employed in high-throughput screening assays to identify and characterize novel therapeutics targeting cholesterol-related pathways and enzymes.
• Metabolic Pathway Analysis: Acts as a tracer in metabolic flux studies to delineate specific enzymatic steps in sterol synthesis without the use of radioisotopes.
• Reference Standard: Utilized as an analytical standard in chromatography (HPLC, GC) and mass spectrometry for the quantification and identification of sterols.
• Lipidomics: A critical component in lipidomic studies to understand the complex roles of modified sterols in health and disease states.

Basic Information

Product Name	6-Fluorocholesterol
CAS No.	86361-68-4
Molecular Formula	C27H45FO
Molecular Weight	404.65 g/mol
Synonyms	6-Fluoro-5-cholesten-3β-ol; (3β)-6-Fluorocholest-5-en-3-ol; 6-Fluoro Cholesterol; 6-F-Cholesterol; Fluorocholesterol; 6-Fluoro-3β-hydroxycholest-5-ene; 6-Fluorocholest-5-en-3β-ol; 6-Fluoro-5-cholesten-3β-ol (6-Fluorocholesterol)
EINECS	Contact for details

Quality Control

Our 6-Fluorocholesterol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.