Description

Trimethyl 4-Phosphonocrotonate is a high-purity organophosphorus compound, specifically a phosphonate ester, that serves as a versatile and critical building block in advanced organic synthesis. Its primary value lies in its role as a key reagent in the Horner-Wadsworth-Emmons (HWE) olefination reaction, enabling the precise and efficient construction of complex molecules with defined stereochemistry. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for developing active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A crucial reagent for synthesizing complex drug molecules, particularly those containing α,β-unsaturated carbonyl systems and other olefinic structures via the Horner-Wadsworth-Emmons reaction.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and plant growth regulators where specific alkene geometry is required for biological activity.
• Specialty Chemical Manufacturing: Serves as a building block for creating fine chemicals, flavors, fragrances, and functional materials that incorporate phosphonate or specific olefin functionalities.
• Academic & Industrial R&D: A valuable tool for synthetic organic chemists in both university and corporate settings for method development and the exploration of new chemical entities.
• Material Science Precursor: Employed in the synthesis of monomers or ligands for polymers, coatings, and metal-organic frameworks (MOFs).

Basic Information

Product Name	Trimethyl 4-Phosphonocrotonate
CAS No.	86120-40-3
Molecular Formula	C7H13O5P
Molecular Weight	208.15 g/mol
Synonyms	Trimethyl (E)-4-phosphonocrotonate; (E)-Trimethyl 4-phosphonobut-2-enoate; Diethyl (E)-4-methoxycarbonylbut-2-enylphosphonate (common precursor/related compound); Phosphonocrotonic Acid Trimethyl Ester; 4-Phosphonocrotonic Acid Trimethyl Ester; But-2-enoic acid, 4-phosphono-, trimethyl ester; HWE Reagent (for crotonate-type olefination)
EINECS	Contact for details

Quality Control

Our Trimethyl 4-Phosphonocrotonate is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the exacting standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Store away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isomeric Purity (E/Z ratio)	≥ 95:5 (E:Z)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.