Description

Hydroxylamine, o-[(1,1-Dimethylethoxy)Carbonyl]- is a protected hydroxylamine derivative, specifically a tert-butoxycarbonyl (Boc) protected hydroxylamine, serving as a crucial building block in organic synthesis. This compound matters for its role in introducing the hydroxylamine functional group under controlled conditions, enabling the synthesis of complex molecules like hydroxamic acids, oximes, and other nitrogen-oxygen containing structures. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key reagent for the synthesis of hydroxamic acid-based drug candidates, including histone deacetylase (HDAC) inhibitors.
• Agrochemical Synthesis: Used in constructing herbicidal and fungicidal agents that incorporate oxime or hydroxamate moieties.
• Peptide & Protein Modification: Employed in bioconjugation chemistry to introduce specific chemical handles or protective groups.
• Polymer Chemistry: Serves as a functional monomer or chain transfer agent in the production of specialty polymers.
• Material Science: Used in surface functionalization and the creation of novel organic-inorganic hybrid materials.
• Chemical Biology Probes: Integral for developing activity-based probes and other tools for studying enzymatic function.

Basic Information

Product Name	Hydroxylamine, o-[(1,1-Dimethylethoxy)Carbonyl]-
CAS No.	86031-24-5
Molecular Formula	C5H11NO3
Molecular Weight	133.15 g/mol
Synonyms	O-(tert-Butoxycarbonyl)hydroxylamine; Boc-NHOH; N-Boc-hydroxylamine; tert-Butyl N-hydroxycarbamate; Hydroxylamine, O-[(1,1-dimethylethoxy)carbonyl]-; O-(tert-Butyloxycarbonyl)hydroxylamine; N-(tert-Butoxycarbonyl)hydroxylamine; Boc-hydroxylamine
EINECS	Contact for details

Quality Control

Our Hydroxylamine, o-[(1,1-Dimethylethoxy)Carbonyl]- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and titration methods, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	86 - 90 °C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.