Description

n-α-Trityl-o-Methyl-L-Homoserine Diethylamine is a sophisticated, protected amino acid derivative primarily used as a key chiral building block in advanced organic synthesis. This compound is critical for researchers and manufacturers requiring high-purity intermediates for the development of complex peptides and other bioactive molecules. It is essential for pharmaceutical R&D, particularly in the synthesis of novel therapeutic agents and in academic research focused on asymmetric synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon in the multi-step synthesis of complex peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) where the trityl (Trt) group serves as a protecting group for the α-amino function.
• Medicinal Chemistry Research: Employed in the design and construction of novel molecular scaffolds for biological screening and structure-activity relationship (SAR) studies.
• Asymmetric Synthesis: Serves as a starting material or intermediate in catalytic asymmetric reactions to introduce homoserine derivatives with high enantiomeric purity.
• Bioconjugation Chemistry: Useful for preparing modified amino acids for protein labeling or the development of antibody-drug conjugates (ADCs).
• Academic & Institutional Research: A valuable reagent for universities and research institutes conducting studies in organic chemistry, chemical biology, and drug discovery.

Basic Information

Product Name	n-α-Trityl-o-Methyl-L-Homoserine Diethylamine
CAS No.	85918-00-9
Molecular Formula	C30H38N2O3
Molecular Weight	474.64 g/mol
Synonyms	L-Homoserine, O-methyl-, N-(triphenylmethyl)-, compd. with N-ethylethanamine (1:1); N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-methyl-L-homoserine; Fmoc-Homoserine(Me)-OH; N-α-Trityl-O-methyl-L-homoserine diethylamine salt; (2S)-2-[(Triphenylmethyl)amino]-4-methoxybutanoic acid compound with N-ethylethanamine; Protected L-Homoserine derivative; Trt-Homoserine(Me)-OH diethylamine salt
EINECS	Contact for details

Quality Control

Our n-α-Trityl-o-Methyl-L-Homoserine Diethylamine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and cGMP applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific project requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation [α]D20	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.