Description

Bis[(9S)-10,11-Dihydro-9-Hydroxy-6'-Methoxycinchonanium] Sulphate is a high-purity, chiral quaternary ammonium salt derived from cinchona alkaloids, serving as a critical intermediate and catalyst in sophisticated organic synthesis. Its primary value lies in its role as a highly effective phase-transfer catalyst (PTC) and chiral selector, enabling asymmetric transformations with high enantioselectivity. This compound is essential for research and production in the pharmaceutical industry, particularly for the synthesis of active pharmaceutical ingredients (APIs), and in fine chemical manufacturing where precise stereochemical control is paramount.

Application

• Asymmetric Phase-Transfer Catalysis (PTC): A key catalyst for enantioselective alkylation, Michael addition, and other carbon-carbon bond-forming reactions under mild conditions.
• Pharmaceutical Intermediate Synthesis: Critical for the production of chiral drugs and complex molecules in API development and manufacturing.
• Chiral Resolution Agent: Used to separate enantiomers of racemic mixtures in analytical and preparative chromatography.
• Fine Chemical Synthesis: Enables the synthesis of specialty chemicals, flavors, fragrances, and advanced materials requiring high enantiomeric purity.
• Academic & Industrial Research: A valuable tool for methodological development in organic chemistry and catalysis research.
• Ligand for Metal Complexes: Can be utilized to form chiral ligands for transition metal-catalyzed asymmetric reactions.

Basic Information

Product Name	Bis[(9S)-10,11-Dihydro-9-Hydroxy-6'-Methoxycinchonanium] Sulphate
CAS No.	85909-61-1
Molecular Formula	C42H52N4O6S
Molecular Weight	740.95 g/mol
Synonyms	Bis(10,11-dihydro-9-hydroxy-6'-methoxycinchonan-9-ium) sulfate; (9S)-10,11-Dihydro-9-hydroxy-6'-methoxycinchonan-9-ium sulfate (2:1); Cinchonan-9-ium, 10,11-dihydro-9-hydroxy-6'-methoxy-, (9S)-, sulfate (2:1); Dihydroquinidine sulfate dimer; Phase-transfer catalyst derived from dihydroquinidine; PTC-Catalyst (DHQD)2SO4; Asymmetric catalyst 85909-61-1.
EINECS	Contact for details

Quality Control

Our Bis[(9S)-10,11-Dihydro-9-Hydroxy-6'-Methoxycinchonanium] Sulphate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure compliance with high-grade specifications suitable for catalytic and synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and performance consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Enantiomeric Excess)	≥ 99.0% ee
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.