Description

2,4-Dichlorophenylmethylsulfone is an aromatic sulfone compound featuring two ortho/para-chlorine substituents on the phenyl ring and a methylsulfonyl group. It serves as a high-value specialty intermediate in the synthesis of advanced agrochemicals and pharmaceutical actives, where structural precision and halogenated sulfone motifs confer enhanced metabolic stability and target affinity. This compound is primarily utilized by R&D laboratories and fine chemical manufacturers developing next-generation herbicides, antifungal agents, and kinase inhibitors. Its consistent purity profile and batch-to-batch reproducibility make it critical for regulated process development and scale-up.

Application

• Synthesis of selective auxin-mimetic herbicides targeting broadleaf weeds in cereal crops
• Key building block in the preparation of sulfone-containing antifungal agents (e.g., analogues of fluquinconazole)
• Intermediate in medicinal chemistry for SAR studies of chlorinated aryl sulfones as B-Raf or EGFR kinase modulators
• Reagent in cross-coupling reactions (e.g., Suzuki, Buchwald–Hartwig) for constructing biaryl sulfone pharmacophores
• Starting material for radiolabeled derivatives used in ADME and PET tracer development
• Functional monomer in high-performance polymer research (e.g., polyethersulfones with enhanced thermal oxidative stability)

Basic Information

Product Name	2,4-Dichlorophenylmethylsulfone
CAS No.	85901-48-0
Molecular Formula	C7H6Cl2O2S
Molecular Weight	225.10 g/mol
Synonyms	2,4-Dichlorobenzenemethyl sulfone; (2,4-Dichlorophenyl)(methyl)sulfone; Methyl(2,4-dichlorophenyl)sulfone; 2,4-Dichlorophenyl methyl sulfone; NSC 632112; UNII-7Z8V2R5T7U; MLS000521704; AKOS025961856
EINECS	Not listed

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches conform to stringent internal specifications aligned with ACS Reagent Grade criteria for organic intermediates, including identity confirmation (IR, HPLC retention time), assay purity (>98.5%), and heavy metal limits (<10 ppm). Testing is performed in ISO/IEC 17025-accredited laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store at room temperature (15–25°C) in a dry, well-ventilated area. Keep away from strong oxidizing agents and reducing substances.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identity (IR)	Conforms to reference standard
Assay (HPLC)	≥98.5%
Melting Point	112–116°C
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	<10 ppm
Chloride (as Cl⁻)	<50 ppm
Water (Karl Fischer)	<0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.