Description

3-Quinolinecarboxylicacid,8-Amino-1,4-Dihydro-4-Oxo-(9Ci) is a nitrogen-containing heterocyclic carboxylic acid derivative featuring a quinolone core with an amino and oxo substituent at key positions. This compound serves as a high-value synthetic intermediate in the development of bioactive molecules, particularly for pharmaceutical research requiring precise structural motifs. It is primarily utilized by medicinal chemists, contract research organizations (CROs), and API manufacturers engaged in antibiotic, antiviral, or kinase inhibitor discovery programs.

Application

• Key building block in the synthesis of fluoroquinolone-class antibacterial agents
• Intermediate for novel tyrosine kinase inhibitors targeting oncology therapeutics
• Substrate in metal-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald–Hartwig) to access functionalized quinolone libraries
• Starting material for preparing fluorescent probes and chelating ligands in diagnostic imaging agent development
• Research reagent in structure–activity relationship (SAR) studies of DNA gyrase/topoisomerase IV inhibitors
• Component in high-throughput screening (HTS) compound collections for antimicrobial target validation

Basic Information

Product Name	3-Quinolinecarboxylicacid,8-Amino-1,4-Dihydro-4-Oxo-(9Ci)
CAS No.	85883-98-3
Molecular Formula	C10H7N3O2
Molecular Weight	201.18 g/mol
Synonyms	8-Amino-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid; 8-Amino-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; 8-Amino-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid; NSC 632329; Quinolone-3-carboxylic acid, 8-amino-1,4-dihydro-4-oxo-; 8-Amino-4-oxo-1,4-dihydroquinoline-3-carboxylate; 3-Carboxy-8-amino-1,4-dihydro-4-oxoquinoline; 8-Amino-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches conform to stringent purity and identity criteria appropriate for research-grade and pharmaceutical intermediate use, including full spectral verification (IR, HPLC, NMR) and trace metal impurity profiling per USP & ICH Q3D guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at room temperature (15–25°C) in a dry, well-ventilated area. Keep away from strong acids, organic solvents, fluorides, and strong alkalis. Avoid exposure to moisture and atmospheric oxygen to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Assay (HPLC)	≥ 98.5%
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Related Substances (HPLC)	Single impurity ≤ 0.3%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.