Description

4-Iodospiperone is a high-purity iodinated derivative of the butyrophenone class, serving as a critical intermediate and reference standard in advanced pharmaceutical research and development. Its primary value lies in enabling precise biochemical studies, particularly in the field of neuropharmacology and receptor binding assays. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who require reliable, well-characterized chemical tools for drug discovery and analytical method development.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel neuroactive compounds and potential therapeutic agents.
• Biochemical Research: Used as a reference standard and ligand in dopamine receptor (particularly D2) binding studies and pharmacological profiling.
• Radiopharmaceutical Precursor: Serves as a precursor molecule for the development of iodinated radiotracers used in Positron Emission Tomography (PET) imaging.
• Analytical Standard: Provides a certified reference material for quality control and method validation in analytical laboratories (HPLC, LC-MS).
• Metabolite Studies: Employed in the investigation of drug metabolism and pharmacokinetics (DMPK) for related pharmaceutical compounds.

Basic Information

Product Name	4-Iodospiperone
CAS No.	85562-22-7
Molecular Formula	C23H26FIN2O2
Molecular Weight	508.37 g/mol
Synonyms	4'-Iodospiperone; 8-[4-(4-Iodophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one; Iodospiperone; Spiperone, 4'-iodo-; 1'-(4-(p-Iodophenyl)-4-oxobutyl)spiro[benzimidazoline-4,4'-piperidin]-2-one
EINECS	Contact for details

Quality Control

Our 4-Iodospiperone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent internal specifications. We support cGMP (current Good Manufacturing Practice) standards for applications requiring the highest level of quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.