Description

Benzidine n-Glucuronide is a crucial glucuronide conjugate of benzidine, a compound of significant interest in toxicological and metabolic research. This reference standard is essential for analytical method development and validation, particularly in the detection and quantification of benzidine metabolites. It serves as a vital tool for researchers and quality control laboratories in the pharmaceutical, environmental monitoring, and occupational safety sectors. The compound's defined structure provides a reliable benchmark for ensuring accurate and reproducible analytical results.

Application

• Analytical Reference Standard: Primary use as a high-purity calibrant and control for HPLC, LC-MS, and GC-MS analysis.
• Metabolite Profiling: Critical for studying the metabolic pathways and biotransformation of benzidine in biological systems.
• Toxicology Research: Used in assays to investigate the excretion, bioactivation, and detoxification mechanisms of aromatic amines.
• Method Development & Validation: Essential for developing and validating sensitive and specific analytical methods in compliance with regulatory guidelines (e.g., FDA, EPA).
• Biomarker Analysis: Supports the quantification of benzidine-glucuronide conjugates as potential biomarkers of exposure in occupational health studies.
• Pharmaceutical Impurity Testing: Can be employed in trace analysis for related compound impurities in certain pharmaceutical syntheses.
• Environmental Analysis: Aids in monitoring benzidine-derived compounds in environmental samples and assessing contamination.

Basic Information

Product Name	Benzidine n-Glucuronide
CAS No.	85559-86-0
Molecular Formula	C18H20N2O6
Molecular Weight	360.36 g/mol
Synonyms	N,N'-Bis(β-D-Glucopyranosiduronic Acid)-4,4'-Diaminobiphenyl; Benzidine Di-β-D-Glucuronide; 4,4'-Diaminobiphenyl Di-β-D-Glucuronide; Benzidine Diglucuronide; Benzidine bis(β-D-Glucuronide); N,N'-Diglucuronosylbenzidine; BZ-DG; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our Benzidine n-Glucuronide is produced under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Each batch is characterized using advanced techniques including NMR, mass spectrometry, and chromatographic methods. A comprehensive Certificate of Analysis (COA) is provided, detailing purity, assay, and impurity profiles. We adhere to stringent quality management protocols to support research requiring reliable and traceable reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. The product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥95.0%
Assay	≥90.0% (on anhydrous basis)
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.